their disease has relapsed twice or more.their disease has come back (relapsed) following a stem cell or bone marrow transplant.newly diagnosed children or young people whose leukaemia hasn’t gone away with 2 cycles of treatment.It will be used in one of the following situations: ![]() Healthcare in Wales and Northern Ireland generally follow NICE guidelines. The following is a summary: Children and young peopleĬAR T-cell is recommended for those up to the age of 25 who have a type of leukaemia called B cell ALL. And decisions by the Scottish Medicines Consortium (SMC) in 2019. This followed decisions by the National Institute for Health and Care Excellence (NICE) in England in December 2018 and January 2019. Examples include:ĬAR T-cell therapy is available for some children with leukaemia and some adults with lymphoma. There are different types of CAR T-cell therapy made by different companies. Researchers are still looking into how long they might stay in the body. The changes they make in the lab mean that they can stay in your body for long periods of time, recognising and attacking the specific cancer cells. The aim is for the CAR T-cells to then recognise and attack the cancer cells. Once there are enough cells you have a drip containing these cells back into your bloodstream. These changed T cells grow and multiply in the lab. These CAR T-cells are designed to recognise and target a specific protein on the cancer cells. CAR stands for chimeric antigen receptor. You might hear this called genetically engineering the T cell. Your medical team take a sample of T cells from your blood. One possible way to do this might be CAR T-cell therapy. Scientists are trying to find ways to get T cells to recognise cancer cells. So the cancer cells can hide away and not be recognised. But it can be difficult for them to tell the difference between a cancer cell and a normal cell. It then keeps some in reserve so that if you come across the infection again your body can recognise it and attack it immediately. When you come into contact with a new infection or disease, the body makes T cells to fight that specific infection or disease. T cells move around the body to find and destroy defective cells. There are different types of lymphocytes. White blood cells called lymphocytes play an important part in fighting infection and diseases, including cancer. To understand CAR T-cell therapy more, it helps to understand what T cells do. People with other types of cancer might have it as part of a clinical trial. ![]() ![]() It is available as a possible treatment for some children with leukaemia and some adults with lymphoma. The CAR T-cells then recognise and attack the cancer cells. After a few weeks, you have a drip containing these cells back into your bloodstream. You might also hear it called a type of adoptive cell transfer.ĬAR T-cell therapy is a very complex and specialist treatment. With this treatment, a specialist collects and makes a small change to your T cells. Go to the cancer types section for information about treatment for your type of cancerĬAR T-cell therapy is a type of immunotherapy.
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